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KMID : 0616120070380020181
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 2 p.181 ~ p.186
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(Phenolic Constituents from the Flowers of Synurus excelsus)
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Lee Il-Kyun
Yang Min-Cheol
Lee Kyu-Ha
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Seven phenolic compounds, scopoletin (1), caffeic acid methyl ester (2), apigenin 7-O-{alpha}-L-rhamnosyl-(1{rightarrow}6)-O-{alpha}-D-glucoside (3), isorhamnetin 7-O-{alpha}-D-glucoside (4), isorhamnetin 3-O-{alpha}-D-glucoside (5), luteolin (6), and quercetin 3-methyl ether (7) were isolated from the methanol extract of the flowers of S. excelsus. Their structures were established by chemical and spectroscopic methods. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a SRB method. The compounds 4 and 7 showed moderate cytotoxicity with ED_{50} values ranging from 1.59 to 13.14{mu}g/ml.
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KEYWORD
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Compositae, Synurus excelsus, phenolic constiuents, Cytotoxicity
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